Potassium Channel

KcsA

Potassium Channel

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Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (882)
Antibodies (6)
Related Compound Screening Libraries (1)

By Effects:	Controls (9) Inhibitors (540) Agonists (14) Antagonists (35) Activators (181) Modulators (30) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-14182

Vernakalant	Inhibitor
Vernakalant(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic.

HY-159506

Bimokalner	Agonist
Bimokalner (Bimokalnerum) is a voltage-gated potassium channel (Kv7.4) agonist.

HY-W654013

Minocycline-d₇	Activator
Minocycline-d₇ is deuterium labeled Minocycline. Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.

HY-14946S

Amifampridine-d₃	Antagonist
Amifampridine-d₃ (3,4-Diaminopyridine-d₃) is deuterium labeled Amifampridine. Amifampridine (3,4-Diaminopyridine) is an orally active, potent and cell permeable voltage-gated potassium (K_v) channel blocker (PCB). Amifampridine is efficacy in the reversal of BoNT/A (HY-P79153) intoxication. Amifampridine increases transmitter release from neuromuscular junctions (NMJs). Amifampridine can be used for Lambert-Eaton myasthenic syndrome (LEMS) research.

HY-P0191

Charybdotoxin	Inhibitor
Charybdotoxin, a 37-amino acid peptide, is a K⁺ channel blocker.

HY-144801A

DDO-02005	Inhibitor
DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC₅₀ value of 0.72 μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl₂-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine.

HY-18277

MK-7145	Inhibitor
MK-7145 is a ROMK inhibitor, with an IC₅₀ of 0.045 μM.

HY-172431

Opakalim	Activator
Opakalim (BHV-7000) is a selective and orally active Kv7.2/7.3 potassium channels activator. Opakalim shows minimal GABAA receptor activation and exhibits potent anti-seizure efficacy in the maximal electroshock seizure (MES) model. Opakalim can be used for the study of seizures.

HY-128829

Kv3 modulator 2	Modulator	99.92%
Kv3 modulator 2 (formula (I)) is a potent Kv3 channels modulator extracted from patent WO2018109484A1, compound formula (I) , has analgesic activity and is used in the prophylaxis or treatment of related disorders.

HY-128831

Kv3 modulator 4	Modulator
Kv3 modulator 4 is a Kv3.1 (pEC₅₀=5.45) and Kv3.2 modulator extracted from patent WO2018020263A1, Cyclobutyl structure.

HY-144801

DDO-02005 free base	Inhibitor
DDO-02005 (free base) is a potent Kv1.5 potassium channel inhibitor with an IC₅₀ value of 0.72 μM. DDO-02005 (free base) has good anti-atrial fibrillation (AF) effect in CaCl₂-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine.

HY-B1751C

Quinine hydrobromide	Inhibitor
Quinidine hydrobromide is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine hydrobromide is also a K⁺ channel blocker with an IC₅₀ of 19.9 μM. Quinidine hydrobromide can be used for malaria research.

HY-102085

11-Deoxyglycyrrhetinic acid sodium	Activator
11-Deoxyglycyrrhetinic acid sodium is a compound that exhibits anti-inflammatory activity. 11-Deoxyglycyrrhetinic acid sodium activates the Ca²⁺/voltage-gated K⁺ large conductance (BK) (cbv1 + β1) channels cloned from rat cerebral artery myocytes with the EC₅₀ of 53 μM.

HY-101422A

GAL-021 sulfate	Inhibitor
GAL-021 sulfate is a potent BK_Ca-channel blocker. GAL-021 sulfate inhibits K_Ca1.1 in GH3 cells. GAL-021 sulfate is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 sulfate increases minute ventilation in rats and non-human primates.

HY-13412

Cariporide (mesilate)	Modulator
Cariporide is a Na+/H+ Exchanger 1 (NHE-1) inhibitor. Cariporide inhibits the expression of monocyte endothelial cell adhesion and intercellular adhesion molecule-1 (ICAM-1) mediated by high glucose (HG) by inhibiting the activation of NHE-1.

HY-152847

Foslevcromakalim	Inhibitor	99.52%
Foslevcromakalim (QLS-101) is a ATP-sensitive potassium channel opener. Foslevcromakalim is the proagent used for ocular hypotensive effect.

HY-153219

P-CAB agent 2 hydrochloride	Inhibitor	≥98.0%
P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 hydrochloride inhibits H⁺/K⁺-ATPase activity with an IC₅₀ value of <100 nM. P-CAB agent 2 hydrochloride inhibits the hERG potassium channel with an IC₅₀ value of 18.69 M. P-CAB agent 2 hydrochloride shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion.

HY-128830

Kv3 modulator 3	Modulator
Kv3 modulator 3 (Compound 4) is a selective modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels extracted from patent WO2017098254A1, compound 4, has analgesic activity for use in the prophylaxis o or treatment of pain.

HY-111996

Kv3 modulator 1	Modulator
Kv3 modulator 1 is a Kv3 voltage-gated potassium channel modulator extracted from patent WO2018020263A1, Compound X. Kv3 modulator 1 has the potential for inflammatory pain treatment.

HY-B0433B

Quinine hemisulfate	Inhibitor
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM.

Potassium Channel Compound Library

Compound library containing a variety of potassium channel inhibitors and activators.

284compounds HY-L119

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (882)

Antibodies (6)

Related Compound Screening Libraries (1)

Potassium Channel Related Products (882):